Anadrol® (Oxymetholone)
by Bill Roberts
Like methandrostenolone (Dianabol), oxymetholone does
not bind well to the androgen receptor (AR), and most of the anabolism
it provides is via non-AR-mediated effects. It is therefore a Class II
steroid and is best stacked with a Class I steroid. The drug appears to
give the same benefits as Dianabol. Unlike Dianabol, however, it seems
that oxymetholone is progestagenic. It has been observed to cause nipple
soreness or to aggravate gynecomastia even in the presence of high dose
antiestrogens, strongly suggesting that the effect is not estrogenic. That
effect can be reduced by concurrent use of stanozolol (Winstrol), which
is anti-progestagenic. This progestagenic effect of oxymetholone is only
a concern when using aromatizing steroids. With androgens such as Primobolan,
oxymetholone stacks very nicely and is a surprisingly friendly drug. In
contrast, with testosterone it is a very harsh drug.
Oxymetholone does not convert to estrogen, and thus antiestrogens
are not required if no aromatizable AAS are being used. However, in concert
with aromatizing drugs, oxymetholone is notorious for worsening "estrogenic"
symptoms, possibly by producing progestagenic symptoms which the bodybuilder
confuses as estrogenic, or by altering estrogen metabolism, or by upregulating
aromatase.
Compared to what bodybuilders expect of it, the drug is
reasonably mild when no aromatizing steroids are present. I consider its
potency approximately comparable to Dianabol. It is not unusual for
a first time user to do quite well on an oxymetholone-only cycle, but more
advanced users will want to stack with another steroid. Typical use
is 50-150 mg/day, which should be divided into several doses per day.
Because oxymetholone is 17-alkylated, it is stressful
to the liver. It is better to limit use to no more than 6 weeks or preferably
four weeks before taking a break of at least equal length. Many users feel
that it is more effectively used in the beginning parts of the cycle, rather
than in the last few weeks.
From mesomorphosis.com |
